Could drugs replace gastric bypass surgery?

(Wiley) Gastric bypass surgery is one of the most successful treatments for obesity and related disorders; however, some patients may not want to undergo surgery. In an attempt to reduce nutrient absorption and replicate the effects of gastric bypass surgery, researchers screened for inhibitors of an amino acid transporter, called B0AT1, and discovered a number of agents -- including benztropine, a drug that is already in clinical use -- as promising candidates.